Litaba

Ha re tobane le COVID-19 e lulang e fetoha, mekhoa ea setso ea ho sebetsana le boemo ka tsela e itseng ha e sebetse.
Moprofesa Huang Bo le sehlopha sa Qin Chuan sa CAMS(Chinese Academy of Medical Sciences) ba fumane hore li-macrophages tse lebisitsoeng ho alveolar e ne e le maano a sebetsang a taolo ea pele ea ts'oaetso ea COVID-19, mme ba fumana litlhare tse peli tse sebelisoang hangata moetsong oa litoeba tsa COVID-19.Liphetho tse amehang tsa lipatlisiso li phatlalalitsoe marang-rang koranteng ea machaba ea thuto, phetisetso ea matšoao le kalafo e lebisitsoeng.
"Phuputso ena ha e fane feela ka kalafo e bolokehileng le e sebetsang bakeng sa COVID-19, empa hape le boiteko bo sebete ba ho 'sebelisa lithethefatsi tsa khale bakeng sa ts'ebeliso e ncha', ho fana ka mokhoa o mocha oa ho nahana ho khetha lithethefatsi bakeng sa COVID-19."Huang Bo o ile a hatisa puisanong le moqolotsi oa litaba oa saense le theknoloji letsatsi le leng le le leng ka la 7 Mmesa.
Joaloka balune, alveoli ke karolo ea motheo ea sebopeho sa matšoafo.Sebaka se ka hare sa alveoli se bitsoa pulmonary surfactant layer, e entsoeng ka lera le lesesaane la mafura le protheine ho boloka alveoli e le boemong bo atolositsoeng.Ka nako e ts'oanang, lera lena la lipid le ka arola bokantle ho tsoa kahare ho 'mele.Limolek'hule tsa lithethefatsi tsa mali, ho kenyelletsa le li-antibodies, ha li na bokhoni ba ho feta lera le sebetsang la alveolar.
Le hoja lera la alveolar surfactant le arola bokantle ho tloha ka hare ho 'mele, tsamaiso ea rona ea 'mele ea ho itšireletsa mafung e na le sehlopha sa li-phagocyte tse khethehileng, tse bitsoang macrophages.Li-macrophages tsena li kenella ka har'a alveolar surfactant lera 'me li ka phagocytize likaroloana le likokoana-hloko tse teng moeeng o hemang, e le ho boloka bohloeki ba alveoli.
"Ka hona, hang ha COVID-19 e kena ka alveoli, li-macrophages tsa alveolar li phuthela likaroloana tsa vaerase holim'a lera la lisele tsa tsona ebe li li metsa ka har'a cytoplasm, e koahelang li-vesicles tsa vaerase, tse bitsoang li-endosomes."Huang Bo o itse, "li-endosome li ka isa likaroloana tsa vaerase ho li-lysosomes, e leng setsi sa ho lahla litšila ho cytoplasm, e le ho senya vaerase hore e be li-amino acid le li-nucleotide bakeng sa tšebeliso ea lisele hape."
Leha ho le joalo, COVID-19 e ka sebelisa boemo bo ikhethileng ba li-macrophages tsa alveolar ho baleha li-endosomes, ebe e sebelisa li-macrophages ho ikatisetsa.
"Tlatsing, li-bisphosphonates tse kang alendronate (AlN) li sebelisoa ho phekola lefu la masapo ka ho lebisa tlhokomelo ea macrophages;sethethefatsi sa glucocorticoid e le dexamethasone (DEX) ke sethethefatsi se atisang ho sebelisoa se thibelang ho ruruha.”Huang Bo o re re fumane hore DEX le AlN li ka thibela ka mokhoa o ts'oanang ho thibela kokoana-hloko ho tsoa ho li-endocytosomes ka ho shebana le polelo ea CTSL le boleng ba pH ba li-endosomes ka ho latellana.
Kaha tsamaiso ea tsamaiso e thata ho hlahisa ka lebaka la tšitiso ea lera le sebetsang la alveoli, Huang Bo o re phello ea phekolo e joalo e kopantsoeng e finyelloa ka ho fafatsa ka nko.Ka nako e ts'oanang, motsoako ona o ka boela oa phetha karolo ea hormone e khahlanong le ho ruruha.Kalafo ena ea spray e bonolo, e bolokehile, ha e bitse chelete ebile ho bonolo ho e khothaletsa.Ke leano le lecha la taolo ea pele ea ts'oaetso ea COVID-19.